Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.

@article{Palma2005Tie2IA,
  title={Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.},
  author={Michele De Palma and Mary A Venneri and Rossella Galli and Lucia Sergi Sergi and Letterio Salvatore Politi and Maurilio Sampaolesi and Luigi Naldini},
  journal={Cancer cell},
  year={2005},
  volume={8 3},
  pages={211-26}
}
Bone marrow-derived cells contribute to tumor angiogenesis. Here, we demonstrate that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) (1) are a distinct hematopoietic lineage of proangiogenic cells, (2) are selectively recruited to spontaneous and orthotopic tumors, (3) promote angiogenesis in a paracrine manner, and (4) account for most of the proangiogenic activity of myeloid cells in tumors. Remarkably, TEM knockout completely prevented human glioma… CONTINUE READING
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