Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis

@inproceedings{Campanelli2016Tie2EM,
  title={Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis},
  author={Rita Campanelli and Gabriela Fois and Paolo Catarsi and Valentina Poletto and Laura Villani and Benedetta Gaia Erba and Luigi Maddaluno and Basilio Jemos and Silvia Salmoiraghi and Paola Guglielmelli and Vittorio Abbonante and Christian A Di Buduo and Alessandra Balduini and Alessandra Iurlo and Giovanni Barosi and Vittorio Rosti and Margherita Massa},
  booktitle={PloS one},
  year={2016}
}
Primary myelofibrosis (PMF) is a Philadelphia-negative (Ph-) myeloproliferative disorder, showing abnormal CD34+ progenitor cell trafficking, splenomegaly, marrow fibrosis leading to extensive extramedullary haematopoiesis, and abnormal neoangiogenesis in either the bone marrow or the spleen. Monocytes expressing the angiopoietin-2 receptor (Tie2) have been shown to support abnormal angiogenic processes in solid tumors through a paracrine action that takes place in proximity to the vessels. In… CONTINUE READING