Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.

  title={Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.},
  author={Yaz Y. Kisanuki and Robert E. Hammer and Jun-ichi Miyazaki and S. C. R. Williams and James A. Richardson and Masashi Yanagisawa},
  journal={Developmental biology},
  volume={230 2},
Endocardial cells are thought to contribute at least in part to the formation of the endocardial cushion mesenchyme. Here, we created Tie2-Cre transgenic mice, in which expression of Cre recombinase is driven by an endothelial-specific promoter/enhancer. To analyze the lineage of Cre expressing cells, we used CAG-CAT-Z transgenic mice, in which expression of lacZ is activated only after Cre-mediated recombination. We detected pan-endothelial expression of the Cre transgene in Tie2-Cre;CAG-CAT-Z… 

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