Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

  title={Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche},
  author={Fumio Arai and Atsushi Hirao and Masako Ohmura and Hidetaka Sato and Sahoko Matsuoka and Keiyo Takubo and Keisuke Ito and Gou Young Koh and Toshio Suda},
The quiescent state is thought to be an indispensable property for the maintenance of hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, known as the stem cell niches, is critical for adult hematopoiesis in the bone marrow (BM). Here, we demonstrate that HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and antiapoptotic, and comprise a side-population (SP) of HSCs, which adhere to osteoblasts (OBs) in the BM niche. The interaction of… CONTINUE READING
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Publications referenced by this paper.
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The stem-cell niche theory: lessons from flies

Nature Reviews Genetics • 2002
View 5 Excerpts
Highly Influenced

cultivation, expression of c-Kit and Tie2 in the CD45 cells

R. C. Allsopp, S. Cheshier, I. L. Weissman
Telomere • 2001
View 4 Excerpts
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Isolation of angiopoietin - 1 , a ligand nizing fetal liver , spleen , and bone marrow

S. Davis, T. H. Aldrich, +10 authors G. D. Yancopoulos
Immunity • 1996
View 7 Excerpts
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Angiopoietin-1-induced PI3kinase activation prevents neuronal apoptosis

M. Bernaudin, E. Petit
FASEB J. 17, • 2003
View 1 Excerpt

Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.

Proceedings of the National Academy of Sciences of the United States of America • 2003
View 2 Excerpts

Requirement for the TIE familytive precursors

M. C. presump-Puri, A. Bernstein
Oncogene • 2003

A molecular profile

I. R. ischka, K. A. Moore
Proc. Natl. Acad. Sci. USA • 2002

AKT / PKB phosphoryla - and Disorders of Mineral Metabolism , 3 rd ed .

D. Dowbenko, L. A. Lasky

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