Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

@article{Arai2004Tie2Angiopoietin1SR,
  title={Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche},
  author={Fumio Arai and Atsushi Hirao and Masako Ohmura and Hidetaka Sato and Sahoko Matsuoka and Keiyo Takubo and Keisuke Ito and Gou Young Koh and Toshio Suda},
  journal={Cell},
  year={2004},
  volume={118},
  pages={149-161}
}
The quiescent state is thought to be an indispensable property for the maintenance of hematopoietic stem cells (HSCs). Interaction of HSCs with their particular microenvironments, known as the stem cell niches, is critical for adult hematopoiesis in the bone marrow (BM). Here, we demonstrate that HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and antiapoptotic, and comprise a side-population (SP) of HSCs, which adhere to osteoblasts (OBs) in the BM niche. The interaction of… CONTINUE READING
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