Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS.

@article{Brochard1998TidalVR,
  title={Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on Tidal Volume reduction in ARDS.},
  author={L. Brochard and Françoise Roudot-Thoraval and Eric E Roupie and Christophe Delclaux and Jean Chastre and Enrique Fern{\'a}ndez-Mond{\'e}jar and Eva Clementi and J. Zabala Mancebo and Phillip Factor and Dimitros Matamis and Marco Vito Ranieri and Llu{\'i}s Blanch and Giuseppe Rodi and Herv{\'e} Mentec and Didier Dreyfuss and Montserrat Bosch Ferrer and Christian Brun-Buisson and Martin I. Tobin and François Lemaire},
  journal={American journal of respiratory and critical care medicine},
  year={1998},
  volume={158 6},
  pages={
          1831-8
        }
}
Because animal studies have demonstrated that mechanical ventilation at high volume and pressure can be deleterious to the lungs, limitation of airway pressure, allowing hypercapnia if necessary, is already used for ventilation of acute respiratory distress syndrome (ARDS). Whether a systematic and more drastic reduction is necessary is debatable. A multicenter randomized study was undertaken to compare a strategy aimed at limiting the end-inspiratory plateau pressure to 25 cm H2O, using tidal… CONTINUE READING
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