Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice.

@article{Glaab2001TidalMF,
  title={Tidal midexpiratory flow as a measure of airway hyperresponsiveness in allergic mice.},
  author={Thomas Glaab and Angelika Daser and Armin Braun and Ulrich Neuhaus-Steinmetz and Helmut Fabel and Yves Alarie and Harald Renz},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 3},
  pages={L565-73}
}
A method for the noninvasive measurement of airway responsiveness was validated in allergic BALB/c mice. With head-out body plethysmography and the decrease in tidal midexpiratory flow (EF(50)) as an indicator of airway obstruction, responses to inhaled methacholine (MCh) and the allergen ovalbumin were measured in conscious mice. Allergen-sensitized and -challenged mice developed airway hyperresponsiveness as measured by EF(50) to aerosolized MCh compared with that in control animals. This… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Mouse models of airway responsiveness: physiological basis of observed outcomes and analysis of selected examples using these outcome indicators

  • JM Drazen, PW Finn, GT. De Sanctis
  • Annu Rev Physiol
  • 1999
1 Excerpt

Similar Papers

Loading similar papers…