Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8.

@article{Kim2005Tid1NR,
  title={Tid1 negatively regulates the migratory potential of cancer cells by inhibiting the production of interleukin-8.},
  author={S O Kim and Masaaki Hayashi and Jeng-Fan Lo and Colleen Fearns and Rong Xiang and Gwendal Lazennec and Young Yang and J. Lee},
  journal={Cancer research},
  year={2005},
  volume={65 19},
  pages={
          8784-91
        }
}
Tid1 is the human homologue of the Drosophila tumor suppressor, Tid56. Reducing the expression of Tid1 in MDA-MB231 breast cancer cells enhanced their migration without affecting their survival or growth rate. From microarray screening, we discovered that after Tid1 depletion, the mRNA level of interleukin-8 (IL-8) was significantly increased in these cancer cells, which consequently increased secretion of IL-8 protein by 3.5-fold. The enhanced migration of these Tid1-knockdown cells was… CONTINUE READING
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