Tics in a patient with Parkinson's disease.

@article{Shale1986TicsIA,
  title={Tics in a patient with Parkinson's disease.},
  author={Heidi Shale and Stanley Fahn and Richard P. Mayeux},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1986},
  volume={1 1},
  pages={
          79-83
        }
}
A patient with Gilles de la Tourette syndrome later developed Parkinson's disease in middle age. This was accompanied by a marked reduction in the frequency of tics but levodopa toxicity exacerbated the tics. The dopamine hypothesis of tic disorders is supported by this observation. 
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