Tics and Tourette syndrome

@article{Dale2021TicsAT,
  title={Tics and Tourette syndrome},
  author={Russell C. Dale},
  journal={Journal of the Neurological Sciences},
  year={2021},
  volume={429}
}
  • R. Dale
  • Published 1 October 2018
  • Psychology, Medicine
  • Journal of the Neurological Sciences
Tourette syndrome is a heterogeneous disorder. The genetic basis is complex, and both in utero and ex utero environmental factors may modify the phenotypic expression of the disorder. Inflammation related to aberrations in immune activation appears to play a pathogenic role in some cases. Multiple neurochemical pathways are involved. Rather than being a pure movement problem, tics are now understood to also have a sensory component. This has resulted in new psychological therapeutic strategies… 
View on Wiley
minerva-access.unimelb.edu.au
16 Citations
Highly Influential Citations
1
Background Citations
5

16 Citations

Citation Type

Citation Type

Tics of Trauma: Unique Case of Trauma-Associated Psychogenic Tics in an Adolescent Patient
TLDR
A 16-year-old girl with a history of trauma who initially presented with depression and trauma-related anxiety develops verbal and motor tic-like symptoms that worsened with stress and court proceedings, classified as psychogenic tics secondary to the trauma associated with sexual abuse.
European clinical guidelines for Tourette syndrome and other tic disorders—version 2.0. Part III: pharmacological treatment
TLDR
Overall, treatment of TS should be individualized, and decisions based on the patient’s needs and preferences, presence of co-existing conditions, latest scientific findings as well as on the physician's preferences, experience, and local regulatory requirements are presented.
Comorbid chronic tic disorder and tourette syndrome in children requiring inpatient mental health treatment
TLDR
In the authors' sample, comorbid CTD/TS seem to represent a marker of overall symptom severity as evidenced by longer admissions, which is significant in children needing inpatient treatment.
Incidence of Autism Spectrum Disorder in Youths Affected by Gilles de la Tourette Syndrome Based on Data from a Large Single Italian Clinical Cohort
TLDR
The incidence of GTS and ASD comorbidity in this study was high, and this has several implications in terms of treatment and prognosis.
Enrichment and Correlation Analysis of Serum miRNAs in Comorbidity Between Arnold-Chiari and Tourette Syndrome Contribute to Clarify Their Molecular Bases
TLDR
The dysregulation of the miRNA set is proposed as a potential molecular tool for supporting the current diagnosis of AC, TS, and ACTS by using liquid biopsies, in an unbiased and non-invasive way.
The Histaminergic System in Neuropsychiatric Disorders
TLDR
This review comprehensively summarize recent experimental and clinical findings on the precise role of histaminergic system in neuropsychiatric disorders, including cell-type role and its circuit bases in narcolepsy, schizophrenia, Alzheimer's disease, Tourette's syndrome and Parkinson’s disease.
Tourette syndrome research highlights from 2018
This is the fifth yearly article in the Tourette Syndrome Research Highlights series, summarizing research from 2018 relevant to Tourette syndrome and other tic disorders. The authors briefly…
Target-Specific Effects of Deep Brain Stimulation for Tourette Syndrome: A Systematic Review and Meta-Analysis
TLDR
It is concluded that DBS is a clinically effective treatment option for patients with treatment-refractory Tourette syndrome, with all targets showing comparable improvement rates.
Psychosocial stress, self-esteem, and social adjustment: A moderated mediation analysis in Taiwanese adolescents with Tourette syndrome.
Effect of Jian-Pi-Zhi-Dong Decoction on the Amino Acid Neurotransmitters in a Rat Model of Tourette Syndrome and Comorbid Anxiety Disorder
TLDR
The study revealed that JPZDD was effective in alleviating the behavioral symptoms of both tic and anxiety in the rat model groups, and reversed the mitochondrial dysfunction both in the striatum and cortex in affected animals.
...
...

References

SHOWING 1-10 OF 59 REFERENCES
Gilles de la Tourette Syndrome – Review Article
  • O. Suchowersky
  • Psychology, Medicine
    Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 1994
TLDR
Tourette syndrome is a neurological disorder characterized by the presence of motor and vocal tics and investigations have suggested that the cause may be an abnormality either in the dopaminergic or endorphin receptor system within the basal ganglia.
Tics and Tourette: a clinical, pathophysiological and etiological review
  • R. Dale
  • Medicine, Biology
    Current opinion in pediatrics
  • 2017
TLDR
Investigation of blood cytokines, blood mRNA and brain mRNA expression support the role of a persistent immune activation, and there are similarities with the immune literature of autistic spectrum disorder.
Tourette’s Syndrome and Role of Tetrabenazine
TLDR
Results of a retrospective chart review showed that 2 years’ treatment with tetrabenazine resulted in an improvement in functioning and TS-related symptoms in over 80% of patients, findings that suggest that treatment with ritussenazine may have long-term benefits, and suggest that tetrABenazine may be suitable as add-on therapy in patients for whom additional suppression of tics is required.
From Genetics to Epigenetics: New Perspectives in Tourette Syndrome Research
TLDR
It is proposed that some general epigenetic mechanisms seen in other neuropsychiatric disorders may also play a role in the pathogenesis of Tourette Syndrome.
Pathophysiology of tic disorders
TLDR
A division of the corticobasal ganglia pathway and its interaction with motor, sensory, limbic, and executive networks in each of the components as well as their control by different neuromodulators allows a better understanding of the pathophysiology of TDs as a whole.
Clinical assessment of Tourette syndrome and tic disorders
The role of immune mechanisms in Tourette syndrome
The Inheritance of Tourette Disorder: A review.
Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): a multidisciplinary consensus
TLDR
Main epidemiologic, socio-demographic and clinical features characterising OCTD patients are critically identified, along with other specific aspects including Health-Related Quality-of-Life (HRQoL), economic consequences related with the condition and its management, as well as treatment-related issues that need to be further investigated.
The Genetic Etiology of Tourette Syndrome: Large-Scale Collaborative Efforts on the Precipice of Discovery
TLDR
These complementary large-scale efforts are joining forces to uncover the full range of genetic variation and environmental risk factors for TS, holding great promise for identifying definitive TS susceptibility genes and shedding light into the complex pathophysiology of this disorder.
...
...