Tics and Tourette: a clinical, pathophysiological and etiological review

@article{Dale2017TicsAT,
  title={Tics and Tourette: a clinical, pathophysiological and etiological review},
  author={Russell C. Dale},
  journal={Current Opinion in Pediatrics},
  year={2017},
  volume={29},
  pages={665–673}
}
  • R. Dale
  • Published 1 December 2017
  • Medicine, Biology
  • Current Opinion in Pediatrics
Purpose of review Describe developments in the etiological understanding of Tourette syndrome. Recent findings Tourette syndrome is a complex heterogenous clinical syndrome, which is not a unitary entity. Pathophysiological models describe gamma-aminobutyric acid-ergic-associated disinhibition of cortico-basal ganglia motor, sensory and limbic loops. MRI studies support basal ganglia volume loss, with additional white matter and cerebellar changes. Tourette syndrome cause likely involves… 
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