Ticlopidine and clopidogrel.

  title={Ticlopidine and clopidogrel.},
  author={Martin J. Quinn and Desmond J. Fitzgerald},
  volume={100 15},
The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation with these compounds is delayed until 24 to 48 hours after administration. Maximum inhibition occurs after 3 to 5 days, and recovery is slow after drug withdrawal. Ticlopidine is… CONTINUE READING


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