Ticlopidine and Antiplatelet Therapy

@article{FloresRunk1993TiclopidineAA,
  title={Ticlopidine and Antiplatelet Therapy},
  author={Patricia Flores-Runk and Ralph H. Raasch},
  journal={Annals of Pharmacotherapy},
  year={1993},
  volume={27},
  pages={1090 - 1098}
}
OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical efficacy, and toxicity of ticlopidine. Comparisons with other antiplatelet agents are presented, with an emphasis on efficacy, and a recommendation is provided regarding ticlopidine's place in therapy. DATA SOURCES: A MEDLINE literature retrieval of English-language journal articles from 1987 to January 1993 and references identified from bibliographies of review articles and clinical trials. STUDY SELECTION: Randomized, blind… 

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TLDR
The second case reported in the literature of the association of Ticlopidine and severe aplastic anaemia is described, where the coexistence in this last case of hypothyroidism confuses the possible role of the drug as a cause of marrow depression.
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TLDR
It is concluded that ticlopidine may well be used instead of anticoagulants for prevention of postoperative occlusion of aorto-coronary bypass grafts.
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TLDR
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TLDR
Evidence is provided of a beneficial effect of ticlopidine in both men and women with a recent thromboembolic stroke, and a smaller estimate of risk reduction for stroke, myocardial infarction, or vascular death is given.
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TLDR
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TLDR
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TLDR
In the relatively randomly selected patient population from one Finnish center, a combination of dipyridamole and acetylsalicylic acid is as effective in women as in men in the prevention of stroke or death.
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TLDR
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