Ticlopidine and Antiplatelet Therapy

@article{FloresRunk1993TiclopidineAA,
  title={Ticlopidine and Antiplatelet Therapy},
  author={Patricia Flores-Runk and Ralph H. Raasch},
  journal={Annals of Pharmacotherapy},
  year={1993},
  volume={27},
  pages={1090 - 1098}
}
OBJECTIVE: To review the pharmacology, pharmacokinetics, clinical efficacy, and toxicity of ticlopidine. Comparisons with other antiplatelet agents are presented, with an emphasis on efficacy, and a recommendation is provided regarding ticlopidine's place in therapy. DATA SOURCES: A MEDLINE literature retrieval of English-language journal articles from 1987 to January 1993 and references identified from bibliographies of review articles and clinical trials. STUDY SELECTION: Randomized, blind… 
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38 Citations
Background Citations
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Methods Citations
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References

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TLDR
The second case reported in the literature of the association of Ticlopidine and severe aplastic anaemia is described, where the coexistence in this last case of hypothyroidism confuses the possible role of the drug as a cause of marrow depression.
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TLDR
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TLDR
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TLDR
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TLDR
During the first two weeks after AMI significant changes in coagulation parameters and fibrinolysis indicated an increased risk of thrombosis in both groups, but these parameters were unaffected by the platelet inhibitory therapy.
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TLDR
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TLDR
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TLDR
Platelet aggregation in response to all doses of ADP was depressed more by T than by ASA, and responses to adrenaline, and arachidonate were affected more by ASA than by T, while for all other agents, differences were not significant.
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