Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells.

@article{Cavassani2005TickSI,
  title={Tick saliva inhibits differentiation, maturation and function of murine bone-marrow-derived dendritic cells.},
  author={Karen A Cavassani and J{\'u}lio C. S. Aliberti and Alexandra R V Dias and Jo{\~a}o S. Silva and Beatriz Rossetti Ferreira},
  journal={Immunology},
  year={2005},
  volume={114 2},
  pages={235-45}
}
Haematophagous arthropod vectors such as mosquitoes, tsetse flies, sandflies and ticks have evolved salivary immunomodulatory factors that prevent the vertebrate host from rejecting them meanwhile enhancing pathogen transmission. As dendritic cells (DC) play a major role in host immune responses, we studied the effects of Rhipicephalus sanguineus tick saliva on DC differentiation and maturation. Flow cytometry analysis revealed that the addition of saliva to bone marrow cells inhibits the… CONTINUE READING

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