Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin.

  title={Tick-borne encephalitis virus neutralization by high dose intravenous immunoglobulin.},
  author={Jana Elsterov{\'a} and Martin Palus and Jana {\vS}irmarov{\'a} and J{\'a}n Kopeck{\'y} and H. H. Niller and Daniel Rů{\vz}ek},
  journal={Ticks and tick-borne diseases},
  volume={8 2},
Tick-borne encephalitis (TBE) is a potentially lethal neuroinfection in humans, caused by TBE virus (TBEV). Currently, there are no approved therapeutic agents to treat TBE. Previously, it was suggested that application of high dose intravenous immunoglobulin (IVIG) may pose potentially successful treatment for severe cases of TBE. In this study, we determined the titers of TBEV-neutralizing antibodies in two IVIG lots originating from the same manufacturer, and tested their ability to treat a… CONTINUE READING
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Fatal tick-borne encephalitis in an immunosuppressed 12-year-old patient.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology • 2016