Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity.

@article{Palus2017TickborneEV,
  title={Tick-borne encephalitis virus infects human brain microvascular endothelial cells without compromising blood-brain barrier integrity.},
  author={Martin Palus and Marie Vancov{\'a} and Jana {\vS}irmarov{\'a} and Jana Elsterov{\'a} and Jan Perner and Daniel Rů{\vz}ek},
  journal={Virology},
  year={2017},
  volume={507},
  pages={110-122}
}
Alteration of the blood-brain barrier (BBB) is a hallmark of tick-borne encephalitis (TBE), a life-threating human viral neuroinfection. However, the mechanism of BBB breakdown during TBE, as well as TBE virus (TBEV) entry into the brain is unclear. Here, primary human microvascular endothelial cells (HBMECs) were infected with TBEV to study interactions with the BBB. Although the number of infected cells was relatively low in culture (<5%), the infection was persistent with high TBEV yields… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS