Tick (Ixodes holocyclus) paralysis in the dog--induction of immunity by injection of toxin.

Abstract

Three beagle dogs were immunised against the paralysing effects of holocyclotoxin, using toxic extracts derived from salivary glands of the Australian paralysis tick, Ixodes holocyclus. Upon subsequent challenge with four ED50's of toxin the animals were completely immune, whereas during the early stages 2 of 3 dogs became paralysed after injection with 0.5… (More)

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