Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials.

@article{James2013TicagrelorIP,
  title={Ticagrelor in patients with acute coronary syndromes and stroke: interpretation of subgroups in clinical trials.},
  author={Stefan Karl James and Karen S. Pieper and Christopher Paul Cannon and Robert F. Storey and Richard C. Becker and Philippe Gabriel Steg and Lars Wallentin and Robert A. Harrington},
  journal={Stroke},
  year={2013},
  volume={44 5},
  pages={1477-9}
}
P hase 3 prospective randomized trials are designed and have statistical power for the investigation of 1 major hypothesis in a predefined population using predefined clinical end points. These large outcome trials are conducted following rules and regulations specified by Good Clinical Practice and the ethical principles of the Declaration of Helsinki to maintain the highest scientific validity and ethical standards and minimize bias. Predefined, subgroup analyses are by definition… CONTINUE READING
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