Tibolone is not converted by human aromatase to 7α-methyl-17α-ethynylestradiol (7α-MEE): Analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS

@article{Gooyer2003TiboloneIN,
  title={Tibolone is not converted by human aromatase to 7$\alpha$-methyl-17$\alpha$-ethynylestradiol (7$\alpha$-MEE): Analyses with sensitive bioassays for estrogens and androgens and with LC-MSMS},
  author={M. D. Gooyer and H. M. Oppers-Tiemissen and D. Leysen and H. Verheul and H. Kloosterboer},
  journal={Steroids},
  year={2003},
  volume={68},
  pages={235-243}
}
To exclude that aromatization plays a role in the estrogenic activity of tibolone, we studied the effect tibolone and metabolites on the aromatization of androstenedione and the aromatization of tibolone and its metabolites to 7alpha-methyl-17alpha-ethynylestradiol (7alpha-MEE) by human recombinant aromatase. Testosterone (T), 17alpha-methyltestosterone (MT), 19-nortestosterone (Nan), 7alpha-methyl-19-nortestosterone (MENT) and norethisterone (NET) were used as reference compounds. Sensitive in… Expand

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