Tibolone and its effects on bone: a review

@article{Berning2001TiboloneAI,
  title={Tibolone and its effects on bone: a review},
  author={B. Berning and H J Coelingh Bennink and Bcjm Fauser},
  journal={Climacteric},
  year={2001},
  volume={4},
  pages={120 - 136}
}
This review examines the evidence for the effects of tibolone on bone. Tibolone is a synthetic steroid with a mixed (estrogenic–progestogenic–androgenic) hormonal profile. Data suggest a complex receptor-mediated as well as metabolic regulation of the activity of tibolone at target tissue level. It has been shown that tibolone can prevent axial and appendicular bone loss induced by ovariectomy and/or a low calcium diet in young and mature rats. In addition, tibolone increases trabecular and… Expand
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TLDR
Treatment with tibolone for 4 weeks prevented OVX‐induced bone loss by suppressing both bone resorption and bone turnover in a similar way as EE2, however, the frequency of dosing is more important for EE2 than for tIBolone. Expand
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Within 2 yr of treatment, tibolone increases bone mass in the spine and prevents bone loss in the forearm in late postmenopausal women determined by densitometry and several biochemical parameters of bone turnover. Expand
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Since tibolone effected a greater increase in spine BMD than did either conjugated equine estrogen with progestogen or transdermal estradiol alone, it is particularly suitable for older women who often have more advanced osteoporosis and who would not accept a return of cyclical bleeding. Expand
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TLDR
Tibolone suppresses the accelerated bone turnover induced by a combination of ovariectomy and low dietary calcium, and indicates that tibolones may be a potentially useful drug for the treatment of postmenopausal osteoporosis. Expand
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TLDR
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Tibolone can be regarded as an alternative to conventional HRT to prevent postmenopausalBone preservation was observed in all three treatment groups as compared with controls, without significant differences among treatment regimens. Expand
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TLDR
Tibolone prevents early postmenopausal bone loss by inducing an increase in trabecular and phalangeal BD as compared to pretreatment values after 2 years of tibolones. Expand
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