Tibolone and endometrial cancer: a cohort and nested case-control study in the UK.

@article{Vries2005TiboloneAE,
  title={Tibolone and endometrial cancer: a cohort and nested case-control study in the UK.},
  author={Corinne S. de Vries and Susan E Bromley and Hilary Thomas and Richard D. T. Farmer},
  journal={Drug safety},
  year={2005},
  volume={28 3},
  pages={
          241-9
        }
}
OBJECTIVE Case series and spontaneous reports of endometrial cancer have raised the question as to whether the use of tibolone (introduced into the UK in 1991) is associated with an increased risk of endometrial cancer. This study set out to evaluate whether tibolone use is associated with an increased risk of endometrial cancer. METHODS Age-adjusted incidence rate ratios (IRRs) of endometrial cancer were calculated for tibolone use compared with the use of other hormone replacement therapy… CONTINUE READING