Corpus ID: 21045356

Tiazofurin: molecular and clinical action.

  title={Tiazofurin: molecular and clinical action.},
  author={George Weber and No{\'e}mi Prajda and Margit Abonyi and Katherine Y. Look and Guido Tricot},
  journal={Anticancer research},
  volume={16 6A},
UNLABELLED The purpose is to provide an overview of the molecular and clinical impact of tiazofurin. METHOD The biochemical and clinical techniques were reported (1, 2). RESULTS IMP DH activity increased in various animal and human tumors and was particularly high in leukemic blast cells. The increased activity was due to an elevation in the mRNA concentration of type II isozyme. Tiazofurin, a C-nucleoside, was converted in sensitive cells to the active metabolite, TAD, which tightly bound… Expand
Chapter 18. Inosine monophosphate dehydrogenase: Consideration of structure, kinetics, and therapeutic potential
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