Tianeptine: An Antidepressant with Memory-Protective Properties

  title={Tianeptine: An Antidepressant with Memory-Protective Properties},
  author={Phillip R Zoladz and Collin R. Park and Carmen Mu{\~n}oz and Monika Fleshner and David M Diamond},
  journal={Current Neuropharmacology},
  pages={311 - 321}
The development of effective pharmacotherapy for major depression is important because it is such a widespread and debilitating mental disorder. Here, we have reviewed preclinical and clinical studies on tianeptine, an atypical antidepressant which ameliorates the adverse effects of stress on brain and memory. In animal studies, tianeptine has been shown to prevent stress-induced morphological sequelae in the hippocampus and amygdala, as well as to prevent stress from impairing synaptic… 
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Tianeptine in an experimental medicine model of antidepressant action
The negative biases in aspects of emotional processing observed following acute tianeptine administration are at variance with the positive biases generally seen after acute administration of conventional antidepressant drugs, despite tianptine’s putative antidepressant efficacy.
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Tianeptine modulates synaptic vesicle dynamics and favors synaptic mitochondria processes in socially isolated rats
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Preclinical research on stress, memory, and the brain in the development of pharmacotherapy for depression
Tianeptine: a novel atypical antidepressant that may provide new insights into the biomolecular basis of depression.
In reliable animal models of depression tianeptine has been shown to prevent neurodegeneration and decreases in hippocampal volume in response to chronic stress, and provides further support for the hypothesis that depression may involve dysregulation of pathways controlling cellular resilience and that treatment should be directed towards the reversal thereof.
Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
Neurobiological and Clinical Effects of the Antidepressant Tianeptine
The neurobiological properties of tianeptine may provide an explanation not only for its antidepressant activity, but also for its anxiolytic effects in depressed patients and its lack of adverse effects on cognitive function and memory.
Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex
Tianeptine: Potential influences on neuroplasticity and novel pharmacological effects
  • T. Uzbay
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2008
Structural plasticity and tianeptine: cellular and molecular targets
Antidepressant and anxiolytic activities of tianeptine: an overview of clinical trials.
The authors have concluded that tianeptine is effective in depressive disorders as shown both by depression rating scales and subjective impressions of treated patients, and improvement increases regularly with time.
Stress effects in the hippocampus: Synaptic plasticity and memory
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