Tianeptine, a selective enhancer of serotonin uptake in rat brain

@article{Mennini2004TianeptineAS,
  title={Tianeptine, a selective enhancer of serotonin uptake in rat brain},
  author={T. Mennini and E. Mocaer and S. Garattini},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={336},
  pages={478-482}
}
SummaryTianeptine is a tricyclic agent provided with antidepressant activity in experimental models and in clinical trials. In vitro tianeptine and its two principal metabolites have no effects on monoamine uptake, release or neurotransmitter receptor binding. The biochemical effect of tianeptine in vivo after acute or repeated treatment indicates an enhanced serotonin uptake in cortex and hippocampus but not in mesencephalon, with no effect on noradrenaline or dopamine uptake. This enhanced… Expand
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