Tiam1 takes PARt in cell polarity.

  title={Tiam1 takes PARt in cell polarity.},
  author={Alexander E. E. Mertens and D Michiel Pegtel and John G. Collard},
  journal={Trends in cell biology},
  volume={16 6},
Cell polarity is an essential requirement for the proper tissue development of complex organisms. This is underscored by in vivo studies showing that loss of cell polarity contributes to the formation and progression of tumours. Evolutionary conserved multiprotein complexes, such as the Par3-Par6-aPKC or, in short, the Par polarity complex, regulate the establishment of cell polarity. The small Rho GTPases CDC42 and Rac control the activation of the Par polarity complex. Evidence now implicates… CONTINUE READING

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