Tiagabine enhances slow wave sleep and sleep maintenance in primary insomnia.

  title={Tiagabine enhances slow wave sleep and sleep maintenance in primary insomnia.},
  author={James K Walsh and Gary K. Zammit and Paula K. Schweitzer and John Ondrasik and Thomas Roth},
  journal={Sleep medicine},
  volume={7 2},
BACKGROUND AND PURPOSE To evaluate the effect of tiagabine on sleep and next-morning alertness and performance in adult patients with primary insomnia. PATIENTS AND METHODS Patients with primary insomnia, as defined by Diagnostic and Statistical Manual of Mental Disorders--Fourth Edition (DSM-IV), received tiagabine 4, 8, 12, 16 mg, and placebo in a randomized, double-blind, five-period, Latin square, crossover study. Efficacy was assessed using polysomnographic and self-report techniques… CONTINUE READING


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