Tiagabine Pharmacology in Profile

@article{Brodie1995TiagabinePI,
  title={Tiagabine Pharmacology in Profile},
  author={M. Brodie},
  journal={Epilepsia},
  year={1995},
  volume={36}
}
  • M. Brodie
  • Published 1995
  • Chemistry, Medicine
  • Epilepsia
Summary: Tiagabine (TGB) hydrochloride, a nipecotic acid derivative linked to a lipophilic anchor, potently and specifically inhibits uptake of the inhibitory neurotransmitter γ‐aminobu‐tyric acid (GABA) into astrocytes and neurons. With microdial‐ysis, TGB has been shown to increase extracellular overflow of GABA in the midbrain of awake rats. TGB administration prolongs neuronal depolarization induced by iontophoretically applied GABA in hippocampal slices. TGB is effective in a wide range of… Expand
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  • M. Benedetti
  • Chemistry, Medicine
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  • 2000
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