Thyroxine-thyroid hormone receptor interactions.

  title={Thyroxine-thyroid hormone receptor interactions.},
  author={Ben Sandler and Paul D. Webb and James W. Apriletti and Bertrand R. Huber and Marie Togashi and Suzana T Cunha Lima and Sanja Juric and Stefan Nilsson and Richard Wagner and Robert Fletterick and J. D. Baxter},
  journal={The Journal of biological chemistry},
  volume={279 53},
Thyroid hormone (TH) actions are mediated by nuclear receptors (TRs alpha and beta) that bind triiodothyronine (T(3), 3,5,3'-triiodo-l-thyronine) with high affinity, and its precursor thyroxine (T(4), 3,5,3',5'-tetraiodo-l-thyronine) with lower affinity. T(4) contains a bulky 5' iodine group absent from T(3). Because T(3) is buried in the core of the ligand binding domain (LBD), we have predicted that TH analogues with 5' substituents should fit poorly into the ligand binding pocket and perhaps… CONTINUE READING