Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism.

@article{Cleare1996ThyroxineRI,
  title={Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism.},
  author={Anthony J Cleare and Alistair McGregor and Susan M. Chambers and Sheila Dawling and Veronica O'Keane},
  journal={Neuroendocrinology},
  year={1996},
  volume={64 1},
  pages={65-9}
}
Hypothyroidism is associated with both reduced central 5-HT function and an increased incidence of depression. This study tested the hypothesis that the reduced 5-HT function returns to normal with thyroxine replacement therapy. Seven hypothyroid patients were tested before and after adequate thyroxine replacement. Cortisol and prolactin responses to d-fenfluramine, a centrally acting 5-HT-releasing agent, were used as an index of central (hypothalamic) 5-HT responsiveness. 5-HT-mediated… CONTINUE READING

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