Thyroxine induces pancreatic beta-cell apoptosis in rats


Aims/hypothesis. Thyroid hormones reduce glucose tolerance in animals and humans. This effect is accompanied by a reduction in the beta-cell volume of the pancreas. Methods. We studied the underlying mechanism using terminal UTP nick end labelling (TUNEL) and caspase-3 to analyse apoptosis and BrdU labelling of beta-cell proliferation. Results. The reason… (More)
DOI: 10.1007/s00125-002-0842-5


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@article{Joerns2002ThyroxineIP, title={Thyroxine induces pancreatic beta-cell apoptosis in rats}, author={Anne Joerns and Markus Tiedge and Sigurd Lenzen}, journal={Diabetologia}, year={2002}, volume={45}, pages={851-855} }