Thyroxine ameliorates oxidative stress by inducing lipid compositional changes in human lens epithelial cells.

@article{Huang2007ThyroxineAO,
  title={Thyroxine ameliorates oxidative stress by inducing lipid compositional changes in human lens epithelial cells.},
  author={Li Huang and Marta Cecilia Yappert and James Jason Miller and Douglas Borchman},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 8},
  pages={3698-704}
}
PURPOSE Lipid saturation and sphingolipids make model membranes less susceptible to oxidation. A human lens epithelial cell line, HLE B-3, was treated with thyroxine to determine whether this treatment increases lipid saturation and membrane sphingolipids, as it does in other tissues, and if so, to see whether the treatment ameliorates the affects of lipid oxidation. METHODS One group of HLE B-3 cells was treated with thyroxine, and another group was not. Cells were then grown in a normoxic… CONTINUE READING