Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons.

@article{Renaud1979ThyrotropinreleasingHS,
  title={Thyrotropin-releasing hormone selectively depresses glutamate excitation of cerebral cortical neurons.},
  author={Leo P. Renaud and H W Blume and Quentin J Pittman and Yvon A. Lamour and Ai Tee Tan},
  journal={Science},
  year={1979},
  volume={205 4412},
  pages={1275-7}
}
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of… CONTINUE READING
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