Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion.

@article{Tanaka1998ThyrotropinRC,
  title={Thyrotropin receptor cleavage at site 1 does not involve a specific amino acid motif but instead depends on the presence of the unique, 50 amino acid insertion.},
  author={Kunihiko Tanaka and Gregorio D Chazenbalk and S. M. Mclachlan and Basil Rapoport},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 4},
  pages={
          1959-63
        }
}
Thyrotropin (TSH) receptor (TSHR) A and B subunits are formed by intramolecular cleavage of the single chain receptor at two separate sites. The region involved in cleavage at Site 2 has been identified, but previous mutagenesis studies failed to identify Site 1. We now report fortuitous observations on the effect of trypsin on the TSHR that localizes a small region harboring Site 1. Thus, as detected by immunoblotting and by 125I-TSH cross-linking to TSHR expressed on the surface of intact CHO… CONTINUE READING

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