Thyrotropin displacement activity of serum immunoglobulins from patients with Graves' disease.

@article{ODonnell1978ThyrotropinDA,
  title={Thyrotropin displacement activity of serum immunoglobulins from patients with Graves' disease.},
  author={Jeff O'Donnell and K M Trokoudes and J Silverberg and Vas V. Row and R. Della Volpe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1978},
  volume={46 5},
  pages={
          770-7
        }
}
A radioreceptor assay for human thyroid stimulators has been employed in various groups of patients. The ability of Ig to displace the labeled TSH from the receptors is referred to as "TSH displacement activity (TDA)." In active Graves' disease, TDA was above normal in 76% of the cases, and in the remaining patients, it was above the 76th percentile, suggesting that thyroid-stimulating Ig (TSIg) may have been present in all cases, but not always demonstrable by this method. Significant TDA was… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Auto-immunity in the Endocrine System

  • Monographs on Endocrinology
  • 1981
VIEW 5 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Polyglandular autoimmune syndrome: current concepts.

  • CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  • 1988