Thyrotropin controls transcription of the thyroglobulin gene ( in vitro transcription / cDNA clones / propylthiouracil / triiodothyronine / hypophysectomy )

@inproceedings{HEUVERSWYNThyrotropinCT,
  title={Thyrotropin controls transcription of the thyroglobulin gene ( in vitro transcription / cDNA clones / propylthiouracil / triiodothyronine / hypophysectomy )},
  author={BRIGITTE VAN HEUVERSWYN and Catherine Streydio and H. Brocas and Samuel Refetoff and Jacques Dumont and G. Vassart}
}
The availability of rat thyroglobulin cDNA clones was exploited to study the regulation of thyroglobulin gene transcription by thyrotropin (TSH). Groups of rats were subjected to treatments leading to reduction or increase in the rat serum TSH (rTSH) levels. Thyroid gland nuclei were isolated, incubated in vitro in the presence of 32P-labeled uridine triphosphate, and thyroglobulin transcripts were quantitated by hybridization to immobilized rat thyroglobulin cDNA clones. Transcription of the… CONTINUE READING