Thyrotropin binding and adenylate cyclase stimulation in thyroid neoplasms.

  title={Thyrotropin binding and adenylate cyclase stimulation in thyroid neoplasms.},
  author={Orlo Herrick Clark and P. L. Gerend and Timothy Cot{\'e} and Robert A. Nissenson},
  volume={90 2},
Experiments were performed to determine whether thyroid-stimulating hormone (TSH) receptors coupled to adenylate cyclase are present in both benign and differentiated malignant thyroid tumors, and to identify abnormalities in the TSH receptor-adenylate cyclase system in neoplastic thyroid tissue. TSH binding and adenylate cyclase assays were performed under the same in vitro cyclase conditions. 125I-bovine TSH was incubated with an 8,000 X g thyroid or thyroid tumor particulate fraction from… CONTINUE READING