Thyroid transcription factors in development, differentiation and disease

@article{Fernndez2015ThyroidTF,
  title={Thyroid transcription factors in development, differentiation and disease},
  author={Lara P. Fern{\'a}ndez and Ar{\'i}stides L{\'o}pez-M{\'a}rquez and P. Santisteban},
  journal={Nature Reviews Endocrinology},
  year={2015},
  volume={11},
  pages={29-42}
}
Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX, has considerably advanced our understanding of thyroid development, congenital thyroid disorders and thyroid cancer. The TTFs are fundamental to proper formation of the thyroid gland and for maintaining the functional differentiated state of the adult thyroid; however, they are not individually required for precursor cell commitment to a thyroid fate. Although knowledge of the mechanisms involved in… Expand
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