Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.

  title={Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.},
  author={Mariusz W Szkudlinski and Val{\'e}rie Fr{\'e}mont and Cath{\'e}rine Ronin and Bruce D. Weintraub},
  journal={Physiological reviews},
  volume={82 2},
This review focuses on recent advances in the structure-function relationships of thyroid-stimulating hormone (TSH) and its receptor. TSH is a member of the glycoprotein hormone family constituting a subset of the cystine-knot growth factor superfamily. TSH is produced by the pituitary thyrotrophs and released to the circulation in a pulsatile manner. It stimulates thyroid functions using specific membrane TSH receptor (TSHR) that belongs to the superfamily of G protein-coupled receptors (GPCRs… 

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