Thyroid-specific transcription factors control Hex promoter activity.

@article{Puppin2003ThyroidspecificTF,
  title={Thyroid-specific transcription factors control Hex promoter activity.},
  author={Cinzia Puppin and Angela Valentina D'elia and Lucia Pellizzari and Diego Russo and Franco Arturi and Ivan Presta and Sebastiano Filetti and Clifford W Bogue and Lee A. Denson and Giuseppe Damante},
  journal={Nucleic acids research},
  year={2003},
  volume={31 7},
  pages={1845-52}
}
The homeobox-containing gene Hex is expressed in several cell types, including thyroid follicular cells, in which it regulates the transcription of tissue- specific genes. In this study the regulation of Hex promoter activity was investigated. Using co- transfection experiments, we demonstrated that the transcriptional activity of the Hex gene promoter in rat thyroid FRTL-5 cells is approximately 10-fold greater than that observed in HeLa and NIH 3T3 cell lines (which do not normally express… CONTINUE READING

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