Thyroid peroxidase as toxicity target for dithiocarbamates

  title={Thyroid peroxidase as toxicity target for dithiocarbamates},
  author={Marina Marinovich and Marina Guizzetti and F. Ghilardi and Barbara Viviani and Emanuela Corsini and Corrado Lodovico Galli},
  journal={Archives of Toxicology},
In vivo ethylenebisdithiocarbamates and ETU are toxic to the thyroid gland. Since the molecular target of these compounds is thought to be thyroid peroxidase (TPO) which catalyzes the transfer of iodine to thyroglobulin, we examined the effect of these compounds on peroxidative activity in Chinese hamster ovary (CHO) cells transfected with the human TPO gene. The activity was inhibited by 50 μM ETU, 5 μM ziram and 5 μM zineb, the last-mentioned effect being irreversible in the absence of iodide… CONTINUE READING


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