Thyroid origin of Calcitonin

@article{Foster1964ThyroidOO,
  title={Thyroid origin of Calcitonin},
  author={Giraud V. Foster and A. Baghdiantz and M. Ashwini Kumar and Eris Hawley Slack and H. A. Soliman and Ian Macintyre},
  journal={Nature},
  year={1964},
  volume={202},
  pages={1303-1305}
}
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233 Citations
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233 Citations

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A thermo-sensitive polymer, mPEG-PA, modified with charged amino acid lysine was developed, which showed a promising potential for the oral delivery of peptide drugs.
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The gray areas in the interpretation of calcitonin measurement are examined in order to provide a tool to clarify the origin of calcitonin secretion and differentiate the behavior of the two-faced Janus of neuroendocrinology: intra-thyroid (MTC) and extra-thy thyroid NENs.
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Long-term outcome after DNA-based prophylactic neck surgery in children at risk of hereditary medullary thyroid cancer.
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Morphological, hormonal, and molecular changes in different maternal tissues during lactation and post-lactation
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This study focuses on the hormonal, metabolic, molecular, and tissue modifications that occur in mammary glands, bone, intestine, and kidneys in the mother during lactation and post-weaning periods.
C Cell and Follicular Epithelial Cell Precursor Lesions of the Thyroid.
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Putative precursor lesions in the thyroid arising from C cells and follicular epithelial cells are discussed, suggesting that benign follicular lesions may have malignant potential, and there may be a multifocal progression from benign to malignant.
Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms
TLDR
An unprecedented investigation of the evolution of neuropeptide copy-number over a period of ~270 million years is performed by analysing sequence data from over fifty ophiuroid species, with reference to a robust phylogeny, and indicates that the composition of neuroPEptide “cocktails” is functionally important, but with plasticity over long evolutionary time scales.
Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms
TLDR
An unprecedented investigation of the evolution of neuropeptide copy number over a period of approximately 270 Myr is performed by analysing sequence data from over 50 ophiuroid species, with reference to a robust phylogeny, and indicates that the composition of neuroPEptide ‘cocktails’ is functionally important, but with plasticity over long evolutionary time scales.
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References

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FURTHER EVIDENCE FOR CALCITONIN. A RAPID-ACTING HORMONE WHICH LOWERS PLASMA-CALCIUM.
THYROID HYPOCALCEMIC PRINCIPLE AND RECURRENT LARYNGEAL NERVE INJURY AS FACTORS AFFECTING THE RESPONSE TO PARATHYROIDECTOMY IN RATS.
TLDR
It was found that cutting, stretching or burning the recurrent laryngeal nerves resulted in respiratory difficulty and retarded the fall in serum calcium after parathyroidectomy—results similar to those produced by thyroparathyroid surgery.
Use of Ion Exchange Resins to alter the Concentrations of Individual Inorganic Ions in Blood in vivo
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A suitable procedure is reported on the development of a suitable procedure to alter selectively the concentration of any ion in blood perfusing an isolated organ.
Evidence for calcitonin--a new hormone from the parathyroid that lowers blood calcium.
TLDR
It is found that this explanation is too simple and that there are, in fact, 2 hormones from the parathyroid involved—parathormone, released by hypocalcemia, and a hypocalcemic factor, calcitonin, which is released by hypercalcemia.
Parathyroid hormone. Nature and mechanism of action.