Thyroid iodide efflux: a team effort?

@article{Fong2011ThyroidIE,
  title={Thyroid iodide efflux: a team effort?},
  author={P. Fong},
  journal={The Journal of Physiology},
  year={2011},
  volume={589}
}
  • P. Fong
  • Published 2011
  • Chemistry, Medicine
  • The Journal of Physiology
  • Abstract  The thyroid hormones thyroxine (T4) and triiodothyronine (T3) play key roles in regulating development, growth and metabolism in pre‐ and postnatal life. Iodide (I−) is an essential component of the thyroid hormones and is accumulated avidly by the thyroid gland. The rarity of elemental iodine and I− in the environment challenges the thyroid to orchestrate a remarkable series of transport processes that ultimately ensure sufficient levels for hormone synthesis. In addition to actively… CONTINUE READING
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    References

    SHOWING 1-10 OF 86 REFERENCES
    Altered ion transport by thyroid epithelia from CFTR−/− pigs suggests mechanisms for hypothyroidism in cystic fibrosis
    • 40
    • Highly Influential
    Update on intrathyroidal iodine metabolism.
    • J. T. Dunn, A. Dunn
    • Chemistry, Medicine
    • Thyroid : official journal of the American Thyroid Association
    • 2001
    • 167
    Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.
    • 147
    • PDF
    The loss of the chloride channel, ClC-5, delays apical iodide efflux and induces a euthyroid goiter in the mouse thyroid gland.
    • 79
    • Highly Influential
    • PDF
    Kcne2 deletion uncovers its crucial role in thyroid hormone biosynthesis
    • 117
    • PDF
    A coherent organization of differentiation proteins is required to maintain an appropriate thyroid function in the Pendred thyroid.
    • 32
    • PDF
    Lactaturia and Loss of Sodium-dependent Lactate Uptake in the Colon of SLC5A8-deficient Mice*
    • 56
    • PDF
    Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.
    • 177
    • PDF
    Evidence for extracellularly acting cathepsins mediating thyroid hormone liberation in thyroid epithelial cells.
    • 96
    • PDF