Thyroid hormones signaling is getting more complex: STORMs are coming.

  title={Thyroid hormones signaling is getting more complex: STORMs are coming.},
  author={Fr{\'e}d{\'e}ric Flamant and Karine Gauthier and Jacques Samarut},
  journal={Molecular endocrinology},
  volume={21 2},
T3 regulates many physiological and developmental processes by binding to thyroid hormone receptors (TRs). This induces a conformational change of DNA-bound TRs that releases corepressors in favor of coactivators. The associated chromatin modifications induce polymerase II recruitment. Mouse genetic studies clarified the respective contribution of each receptor isoform and revealed the important activity of unliganded TRs. They also confirm the paradoxical negative regulation of some promoters… CONTINUE READING


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