Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells.

@article{Latasa1998ThyroidHR,
  title={Thyroid hormones regulate beta-amyloid gene splicing and protein secretion in neuroblastoma cells.},
  author={Maria Jes{\'u}s Latasa and Borja Belandia and Angel Pascual},
  journal={Endocrinology},
  year={1998},
  volume={139 6},
  pages={2692-2698}
}
The beta-amyloid protein (Abeta), the major component of the senile plaques found in Alzheimer brains, derives from a larger beta-amyloid precursor protein (APP). Alternative splicing of the APP gene yields three major APP messenger RNAs (mRNAs), which, in turn, give rise to the APP770, APP751, and APP695 protein isoforms. In this study we examined the effects of thyroid hormone on APP expression in N2a-beta neuroblastoma cells. T3 caused a significant increase in the APP770 mRNA band, in… CONTINUE READING