Thyroid hormones modulate GABA<ce:inf loc=post>A</ce:inf> receptor-mediated currents in hippocampal neurons

@article{Puia2011ThyroidHM,
  title={Thyroid hormones modulate GABA<ce:inf loc=post>A</ce:inf> receptor-mediated currents in hippocampal neurons},
  author={Giulia Puia and Gabriele Losi},
  journal={Neuropharmacology},
  year={2011},
  volume={60},
  pages={1254-1261}
}
Thyroid hormones (THs) play a crucial role in the maturation and functioning of mammalian central nervous system. Thyroxine (T4) and 3, 3', 5-L-triiodothyronine (T3) are well known for their genomic effects, but recently attention has been focused on their non genomic actions as modulators of neuronal activity. In the present study we report that T4 and T3 reduce, in a non competitive manner, GABA-evoked currents in rat hippocampal cultures with IC₅₀s of 13±4μM and 12±3μM, respectively. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-6 of 6 citations