Thyroid hormones mediated effect of insulin on alloxan diabetic rat atria.

@article{Karasu1990ThyroidHM,
  title={Thyroid hormones mediated effect of insulin on alloxan diabetic rat atria.},
  author={Çimen Karasu and Yusuf Ozt{\"u}rk and Nilg{\"u}n Altan and N Yildizoğlu-ari and Coşkun Ikizler and Vecdi Melih Altan},
  journal={General pharmacology},
  year={1990},
  volume={21 5},
  pages={735-40}
}
1. The influence of alloxan-induced diabetes was studied on spontaneously beating rat atria. Diabetic atria were found to have decreased rates, increased contractility and decreased responsiveness to both inotropic and chronotropic effects of isoprenaline. 2. Thyroid hormone levels were significantly reduced in diabetic animals. This revealed that the decrease in atrial beta-adrenergic responses was associated with a reduction in serum levels of thyroid hormones. 3. Insulin treatment of… CONTINUE READING

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