Thyroid hormones and retinoids: A possible link between genes and environment in schizophrenia

@article{Palha2006ThyroidHA,
  title={Thyroid hormones and retinoids: A possible link between genes and environment in schizophrenia},
  author={Joana Almeida Palha and Ann B. Goodman},
  journal={Brain Research Reviews},
  year={2006},
  volume={51},
  pages={61-71}
}
Phenotypic discordance for schizophrenia in monozygotic twins clearly indicates involvement of environmental factors as key determinants in disease development. Positive findings from genome scans, linkage and association studies apply in only a minority of those affected, while post-mortem brain investigations reveal altered expression of genes and proteins involved in numerous neurodevelopmental, metabolic and neurotransmitter pathways. Such altered expressions could result, on the one hand… Expand
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References

SHOWING 1-10 OF 134 REFERENCES
Schizophrenia, vitamin D, and brain development.
TLDR
It is made the case here that schizophrenia may result not from numerous genes of small effect, but a few genes of transcriptional regulation acting during brain development, and that low vitamin D duringbrain development interacts with susceptibility genes to alter the trajectory of brain development. Expand
Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases
  • Jinong Feng, J. Chen, +6 authors S. Sommer
  • Biology, Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2005
TLDR
It is concluded that structural variants in the RAR/RXR and NURR1 genes do not play a major role in the etiology of schizophrenia. Expand
Three independent lines of evidence suggest retinoids as causal to schizophrenia.
  • A. Goodman
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
TLDR
A close causal relationship between retinoids and the underlying pathophysiological defects in schizophrenia is suggested and new treatment modalities to alter the downstream expression of the dopamine receptors and other genes that are targets of retinoid regulation, and that are thought to be involved in schizophrenia are suggested. Expand
The genes for schizophrenia: Finally a breakthrough?
TLDR
Though credible evidence is available for all of these genes, it is strongest for NRGI andDTNBPI, and further studies, particularly exhaustive analyses of all polymorphisms at each locus, meta-analyses, and investigations of the likely function of risk alleles (variants) are desirable. Expand
Retinoid dysregulation may result in abnormal expression of glutamic acid decarboxylase in schizophrenia.
  • A. Goodman
  • Biology, Medicine
  • Archives of general psychiatry
  • 1996
TLDR
Review of the action and metabolism of genes of the retinoid cascade in relation to schizophrenia indicates that, in addition to controlling for neuronal migration and anterior and posterior positional development of the central nervous system, retinoids are present in all areas of the brain. Expand
NR4A2 and schizophrenia: Lack of association in a Portuguese/Brazilian study
  • D. Ruano, A. Macedo, +11 authors J. Palha
  • Medicine
  • American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2004
TLDR
The present study investigates the association of mutations in the nuclear receptor NR4A2 in schizophrenic patients and failed to identify any of the described mutations, but negative results do not exclude altered expression of nuclear receptors in schizophrenia or the presence of other mutations. Expand
Investigation of a candidate gene for schizophrenia on Xq13 previously associated with mental retardation and hypothyroidism.
TLDR
The findings replicate prior findings demonstrating an association between HOPA polymorphisms and hypothyroidism and the increased frequency of HOPA variants in this population may also provide a genetic basis for the familial association of thyroid disease and schizophrenia. Expand
Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA
TLDR
The authors concluded that the neurodevelopmental consequences of vitamin D deficiency do not play a causative role in psychotic disorders, these two syndromes are inherited independently, and vitamin D deficiencies does not act as a risk factor in subjects susceptible to psychosis. Expand
Genes, environment and schizophrenia.
TLDR
Schizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness. Expand
A high proportion of polymorphisms in the promoters of brain expressed genes influences transcriptional activity.
TLDR
Empirical evidence is provided for the first time empirical evidence that promoter element polymorphisms, at least in brain expressed genes, should be afforded a high priority for molecular genetic studies. Expand
...
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2
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4
5
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