Thyroid hormones and nervous system development.

  title={Thyroid hormones and nervous system development.},
  author={Paola S. Timiras and E U Nzekwe},
  journal={Biology of the neonate},
  volume={55 6},
Regulation by hormones of nervous system development is well recognized in humans, laboratory animals and cultured nerve cells. Thyroxine (T4) and triiodothyronine (T3), the major thyroid hormones, act on brain development and maturation by binding to T3 nuclear receptors. T3 responsive genes have been identified with the T3 receptor as a superfamily of genes including cortisol and estrogens, necessary for adaptation and survival. Less defined are T3 and T4 actions on the peripheral nervous… CONTINUE READING


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