Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak.

@article{Pehowich1999ThyroidHS,
  title={Thyroid hormone status and membrane n-3 fatty acid content influence mitochondrial proton leak.},
  author={Daniel J. Pehowich},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1411 1},
  pages={
          192-200
        }
}
Proton leak, as determined by the relationship between respiration rate and membrane potential, was lower in mitochondria from hypothyroid rats compared to euthyroid controls. Moreover, proton leak rates diminished even more when hypothyroid rats were fed a diet containing 5% of the lipid content as n-3 fatty acids. Similarly, proton leak was lower in euthyroid rats fed the 5% n-3 diet compared to one containing only 1% n-3 fatty acids. Lower proton leaks rates were associated with increased… CONTINUE READING

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