Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.

@article{Rudolph2014ThyroidHR,
  title={Thyroid hormone responsive protein Spot14 enhances catalysis of fatty acid synthase in lactating mammary epithelium.},
  author={Michael C Rudolph and Elizabeth A. Wellberg and Andrew S. Lewis and Kristina L. Terrell and Andrea L. Merz and Nasib Karl Maluf and Natalie J. Serkova and Steven M. Anderson},
  journal={Journal of lipid research},
  year={2014},
  volume={55 6},
  pages={
          1052-65
        }
}
Thyroid hormone responsive protein Spot 14 has been consistently associated with de novo fatty acid synthesis activity in multiple tissues, including the lactating mammary gland, which synthesizes large quantities of medium chain fatty acids (MCFAs) exclusively via FASN. However, the molecular function of Spot14 remains undefined during lactation. Spot14-null mice produce milk deficient in total triglyceride and de novo MCFA that does not sustain optimal neonatal growth. The lactation defect… CONTINUE READING