Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway.

@article{Morte2010ThyroidHR,
  title={Thyroid hormone regulation of gene expression in the developing rat fetal cerebral cortex: prominent role of the Ca2+/calmodulin-dependent protein kinase IV pathway.},
  author={Beatriz Morte and Diego D{\'i}ez and Eva Aus{\'o} and M{\'o}nica M. Belinch{\'o}n and Pilar Gil-Ib{\'a}{\~n}ez and Carmen Grijota-Mart{\'i}nez and Daniela Navarro and Gabriella Morreale de Escobar and P. Pere Berbel and Jaime H. Bernal},
  journal={Endocrinology},
  year={2010},
  volume={151 2},
  pages={810-20}
}
Thyroid hormones influence brain development through regulation of gene expression mediated by nuclear receptors. Nuclear receptor concentration increases rapidly in the human fetus during the second trimester, a period of high sensitivity of the brain to thyroid hormones. In the rat, the equivalent period is the last quarter of pregnancy. However, little is known about thyroid hormone action in the fetal brain, and in rodents, most thyroid hormone-regulated genes have been identified during… CONTINUE READING

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